Hans-Walter Pfister Selected Research

Pneumococcal Meningitis (Streptococcus pneumoniae Meningitis)

1/2018	Mast Cells Are Activated by Streptococcus pneumoniae In Vitro but Dispensable for the Host Defense Against Pneumococcal Central Nervous System Infection In Vivo.
4/2014	Plasminogen activator inhibitor-1 influences cerebrovascular complications and death in pneumococcal meningitis.
1/2014	Leukocyte attraction by CCL20 and its receptor CCR6 in humans and mice with pneumococcal meningitis.
10/2013	Adjunctive N-acetyl-L-cysteine in treatment of murine pneumococcal meningitis.
6/2013	High mobility group box 1 prolongs inflammation and worsens disease in pneumococcal meningitis.
11/2011	The NLRP3 inflammasome contributes to brain injury in pneumococcal meningitis and is activated through ATP-dependent lysosomal cathepsin B release.
11/2010	CXCL16 contributes to neutrophil recruitment to cerebrospinal fluid in pneumococcal meningitis.
3/2009	Simvastatin attenuates leukocyte recruitment in experimental bacterial meningitis.
10/2008	Myeloid Src kinases regulate phagocytosis and oxidative burst in pneumococcal meningitis by activating NADPH oxidase.
2/2007	Complement C1q and C3 are critical for the innate immune response to Streptococcus pneumoniae in the central nervous system.

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Hans-Walter Pfister Research Topics

Disease

22	Bacterial Meningitis 01/2021 - 01/2002
20	Pneumococcal Meningitis (Streptococcus pneumoniae Meningitis) 01/2018 - 01/2002
16	Meningitis 01/2017 - 01/2002
10	Infections 08/2015 - 10/2003
7	Leukocytosis (Pleocytosis) 01/2018 - 04/2003
7	Inflammation (Inflammations) 01/2017 - 01/2002
4	Encephalitis (Encephalitis, Rasmussen) 02/2020 - 11/2010
4	Hearing Loss (Hearing Impairment) 10/2013 - 04/2003
4	Pneumococcal Infections 11/2010 - 01/2003
3	Multiple Sclerosis 06/2015 - 04/2003
3	Brain Injuries (Brain Injury) 11/2011 - 01/2007
3	Viral Meningitis 11/2010 - 04/2003
3	Brain Edema (Cerebral Edema) 01/2007 - 01/2003
2	Seizures (Absence Seizure) 01/2021 - 01/2017
2	Critical Illness (Critically Ill) 02/2020 - 03/2004
2	Hemorrhage 04/2019 - 09/2018
2	Disease Progression 01/2018 - 11/2011
2	Lyme Disease (Disease, Lyme) 01/2017 - 05/2006
2	Systemic Lupus Erythematosus (Libman-Sacks Disease) 06/2015 - 01/2015
2	Autoimmune Diseases (Autoimmune Disease) 06/2015 - 01/2015
2	Stroke (Strokes) 01/2011 - 03/2004
2	Central Nervous System Vasculitis 11/2010 - 09/2006
2	Central Nervous System Infections (Central Nervous System Infection) 10/2008 - 06/2008
2	Intracranial Hemorrhages (Intracranial Hemorrhage) 01/2005 - 01/2003
1	Autoimmune Diseases of the Nervous System 02/2020
1	Brain Abscess (Abscess, Brain) 05/2019
1	Clinical Deterioration 04/2019
1	Venous Thromboembolism 09/2018
1	Subarachnoid Hemorrhage (Aneurysmal Subarachnoid Hemorrhage) 09/2018
1	Thrombocytopenia (Thrombopenia) 09/2018
1	Aneurysm (Aneurysms) 09/2018
1	Fever (Fevers) 01/2018
1	Coma (Comas) 01/2017
1	Intracranial Hypotension 01/2017
1	Post-Lyme Disease Syndrome 08/2015
1	Meningococcal Meningitis 07/2014
1	Sweet Syndrome (Acute Febrile Neutrophilic Dermatosis) 07/2014
1	Cerebral Infarction 04/2014
1	Body Weight (Weight, Body) 10/2013
1	Neurologic Manifestations (Neurological Manifestations) 10/2013

Drug/Important Bio-Agent (IBA)

14	Anti-Bacterial Agents (Antibiotics)IBA 01/2021 - 12/2002
10	ChemokinesIBA 01/2014 - 12/2002
8	CytokinesIBA 11/2011 - 12/2002
7	Proteins (Proteins, Gene)FDA Link 07/2015 - 03/2002
5	Dexamethasone (Maxidex)FDA LinkGeneric 01/2021 - 12/2002
4	Ceftriaxone (Ceftriaxon)FDA LinkGeneric 10/2013 - 10/2003
4	Interleukin-1beta (Interleukin 1 beta)IBA 09/2006 - 01/2002
3	Adrenal Cortex Hormones (Corticosteroids)IBA 02/2020 - 07/2014
3	Toll-Like Receptors (Toll-Like Receptor)IBA 06/2010 - 04/2007
3	Pattern Recognition ReceptorsIBA 06/2010 - 01/2003
3	Interleukin-6 (Interleukin 6)IBA 01/2007 - 01/2003
3	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 06/2004 - 01/2002
3	Messenger RNA (mRNA)IBA 06/2004 - 03/2002
2	InflammasomesIBA 01/2017 - 11/2011
2	Adenosine Triphosphate (ATP)IBA 01/2017 - 11/2011
2	Biomarkers (Surrogate Marker)IBA 06/2015 - 11/2010
2	Immunoglobulin G (IgG)IBA 06/2015 - 01/2015
2	Plasminogen Activator Inhibitor 1IBA 04/2014 - 03/2005
2	AntibodiesIBA 01/2014 - 11/2010
2	Acetylcysteine (Siran)FDA LinkGeneric 10/2013 - 12/2006
2	AntioxidantsIBA 10/2013 - 10/2003
2	Toll-Like Receptor 2IBA 12/2009 - 01/2003
2	Simvastatin (Zocor)FDA LinkGeneric 07/2009 - 03/2009
2	Complement Receptors (Complement Receptor)IBA 10/2008 - 01/2003
2	src-Family KinasesIBA 10/2008 - 01/2007
2	Complement System Proteins (Complement)IBA 02/2007 - 06/2004
2	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 01/2007 - 07/2005
2	NitrogenIBA 12/2006 - 09/2006
2	Macrophage Inflammatory Proteins (Macrophage Inflammatory Protein 1)IBA 06/2004 - 01/2003
2	Chemokine CX3CL1IBA 04/2003 - 02/2003
2	Oxidants (Oxidizing Agents)IBA 12/2002 - 12/2002
2	Peptide Hydrolases (Proteases)FDA Link 12/2002 - 12/2002
1	Antiviral Agents (Antivirals)IBA 02/2020
1	SteroidsIBA 02/2020
1	Acyclovir (Aciclovir)FDA LinkGeneric 04/2019
1	Heparin (Liquaemin)FDA LinkGeneric 09/2018
1	Cromolyn Sodium (Cromoglicic Acid)FDA LinkGeneric 01/2018
1	InterleukinsIBA 01/2017
1	paquinimodIBA 07/2015
1	Toll-Like Receptor 4IBA 07/2015
1	bis(3- bis(4- chlorophenyl)methyl- 4- dimethylaminophenyl)amineIBA 06/2015
1	Amyloid Precursor Protein Secretases (beta-Secretase)IBA 06/2015
1	LigandsIBA 01/2015
1	TACI receptor-IgG Fc fragment fusion proteinIBA 01/2015
1	Plasminogen Activators (Plasminogen Activator)IBA 04/2014
1	ethyl pyruvateIBA 06/2013
1	Phosphatidylinositol 3-Kinases (PI 3 Kinase)IBA 02/2013
1	Streptococcus pneumoniae plY proteinIBA 11/2011

Therapy/Procedure

20	Therapeutics 01/2021 - 01/2002
3	Critical Care (Surgical Intensive Care) 04/2007 - 01/2005
2	Contraindications 01/2021 - 05/2008
2	Decompressive Craniectomy 04/2019 - 03/2004
2	Length of Stay 01/2018 - 01/2011
1	Cesarean Section (Caesarean Section) 01/2017
1	Conservative Treatment 01/2017
1	Complementary Therapies (Alternative Medicine) 01/2017
1	Epidural Anesthesia 01/2017
1	Epidural Blood Patch 01/2017
1	Aftercare (After-Treatment) 08/2015
1	Spinal Injections 07/2015